Research Fellow (Trial Manager, Botswana)

The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world's leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working in partnership to achieve excellence in public and global health research, education and translation of knowledge into policy and practice.

LSHTM is seeking to appoint a Trial Manager within the Clinical Research Department. The post-holder will be responsible for the day-to-day operational management of ADVANCING-CM, a multi-site phase IIb into phase III randomised clinical trial of adjunctive interferon gamma for HIV-associated cryptococcal meningitis in Botswana, Malawi, South Africa and Uganda.

They will work closely with the International Lead Clinician, the experienced senior trial management team and study coordinators at the participating African study sites. The post-holder will be expected to be based full-time at the Trial Coordinating Centre in Gaborone, Botswana for the duration of study recruitment and to travel frequently to the other trial sites.

The role will provide operational leadership across trial set-up, regulatory and ethics processes, site initiation and monitoring, trial documentation, data quality, safety-reporting systems and trial governance, ensuring that the study is conducted in accordance with the protocol, Good Clinical Practice (GCP), applicable regulatory requirements and trial procedures.

The successful candidate will have:
- A postgraduate degree, ideally a doctoral degree, in a relevant topic
- Relevant experience of working on multicentre phase III clinical trials, including Clinical Trials of Investigational Medicinal Products (CTIMPs)
- Experience of trial set-up and site initiation, including preparation and maintenance of essential trial documentation
- Experience of clinical trial monitoring, including identification and follow-up of monitoring findings and protocol deviations

The post is full-time (35 hours per week, 1.0 FTE) and fixed term until 31 December 2030. The post is funded by Coefficient Giving and is available from 01 January 2027. This post is based in Botswana, hosted by the Botswana Harvard Health Partnership Institute in Gaborone, with frequent travel to sites in Malawi, Uganda and South Africa.

The salary will be on the LSHTM salary scale, Grade 6 in the range £46,643 - £52,909 per annum (inclusive of London Weighting). Annual leave entitlement is 30 working days per year, plus discretionary Wellbeing Days. Membership of the Pension Scheme is available.